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[unable to retrieve full-text content]If you find yourself asking where to begin with learning proper finance, start with the definition of personal finance, budgeting. Why the definition of personal finance is budgeting we will outline in the following article, because ...

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Zardari to visit Ajmer in India

Last Updated: Sun, Apr 01, 2012 23:31 hrs

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Pakistan President Asif Ali Zardari would visit Ajmer in India on April 8 to offer prayer at the shrine of Khwaja Moinuddin Chishti amid reports that the opportunity could be used by the host country to pursue diplomacy.

While the visit is purely a private one for Zardari, media reports on Sunday said efforts are on from Indian side to arrange a meeting between the former and Prime Minister Manmohan Singh.

Zardari can bring 12 of his family members during the visit, reports said.

While the Indian Prime Minister met his Pakistan counterpart Yousuf Raza Gilani in recent times (as recent as on Mar 27 last in Seoul), he had last met Zardari in July 2009 on the sidelines of the summit of the Shanghai Cooperation Organisation in Russia.

Nuclear armed neighbours India and Pakistan are talking since early 2010 now with foreign secretary level talks held last year in June.

During the World Cup semifinal in Mohali between Pakistan and India in March 2011, Singh and Gilani had met one the sidelines and over dinner in the much touted cricket diplomacy.

An informal meeting between Singh and Gilani also happened in Seoul on Mar 27 on the sidelines of Nuclear Security Summit.

The two nations are keen to normalize trade relations.

Talks between India and Pakistan were broken after the 26/11 attack in Mumbai in Nov 2008 when Pakistani terrorists launched several coordinated strikes in vital places of India?s financial heart and two luxury hotels, killing 166 people and wounding more than 300.

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Metformin appeared to slow prostate cancer growth

Anthony M. Joshua, M.B.B.S., Ph.D., staff medical oncologist at the Princess Margaret Hospital, University Health Network in Toronto, Ontario, Canada, presented the data at the AACR Annual Meeting 2012, held here March 31 - April 4.

Metformin is the most commonly prescribed medication for diabetes. Prior laboratory research has suggested that metformin may also help to improve prognosis in patients with prostate cancer by slowing the growth of the cancerous cells.

To follow up on the laboratory clues, Joshua and colleagues evaluated 22 men with confirmed prostate cancer who had been assigned up to 500 mg of metformin three times a day prior to undergoing prostatectomy.

"This gave us the ability to compare what the prostate cancer looked like when it was first diagnosed to what it looked like when the prostate cancer was removed from the body," said Joshua. "We were able to directly measure the effect of metformin on the prostate cancer."

Patients were assigned metformin for a median duration of 41 days. During that time, none of the men reported grade 3 adverse events, and all of them underwent prostatectomy with no adverse effect related to use of metformin.

The researchers found that metformin significantly reduced fasting glucose, insulin growth factor-1, body mass index and waist-to-hip ratio.

In addition, "although these are preliminary results, metformin appeared to reduce the growth rate of prostate cancer in a proportion of men," Joshua said. "Also, it appeared to reduce one of the main growth pathways that may have contributed to the overall growth of the tumor."

These results may have implications for men with prostate cancer who also have diabetes or early undiagnosed diabetes and for men with prostate cancer whose tumors have characteristics that make them sensitive to metformin, according to Joshua.

"This research builds on the hypothesis that metformin has a role in prostate cancer," he said. "Exactly what that role will be will depend on the results of the analysis currently being completed by our study team and others worldwide."

Joshua is particularly interested in better defining the precise mechanism of action and the subpopulation of patients with prostate cancer for whom metformin has the potential to improve outcomes.

More information: A phase II study of neoadjuvant metformin in prostatic carcinoma

Abstract
Background: Metformin is an inhibitor of the complex 1 in the respiratory chain, and is widely used in diabetes due to its effect on reducing insulin resistance. It has also been recently described to have effects via AMPK on inhibiting the mTOR kinase. Significant preclinical and epidemiological studies suggest its role in chemoprevention. These actions provide significant rationale to evaluate its utility in prostate cancer. We conducted a phase II single centre study of neoadjuvant metformin in localised prostate cancer.
Methods: Men were required to have histologically confirmed prostate cancer involving at least 20% of at least 1 unfragmented biopsy core. Exclusion criteria included patients who on initial assessment are found to be on treatment with any drug used for the treatment of any form of diabetes, or patients that begin treatment for any form of diabetes during the course of the study. Pts were treated with up to 500mg tid of metformin. The primary objectives were to demonstrate safety and tolerability of neoadjuvant metformin administration in men with prostate cancer and to document changes in phospho-AKT signalling indices.
Results: 24 patients were enrolled with 22 evaluable; median age was 64 yrs (range, 45-70 yrs). Baseline characteristics included median PSA 6 ng/mL (range, 3.22-36.11ng/mL). Median duration of drug treatment was 41 days (range 18-81). No grade 3 adverse events were reported, all patients underwent subsequent radical prostatectomy with adverse effects related to metformin. Significant pre-and post changes were noted in serum IGF1 (p=0.02), fasting glucose (p=0.03), BMI (pConclusions: Neoadjuvant metformin is well tolerated prior to radical prostatectomy. Data to date indicates promising effects on metabolic parameters, tissue results will be presented including proliferation indices and signaling pathway assessments.

Provided by American Association for Cancer Research (news : web)

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Chris Brown enters UK chart at number one

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Ex-Liverpool star Hyypia to coach Leverkusen

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7 Things You Must Consider Before You Start Your Internet ...

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Choosing a web host is not easy, and you will have to consider the background of your website in the process. The characteristics of a free web host and a commercial web host are not entirely similar. A free web host is good enough if your website is more of a personal or experimental site without commercial basis.

There are different categories of free web hosts, such as those with PHP support, free domain hosting, free sharing hosts or free video hosting. Your choice of a web host depends on the purpose and requirements of your website.

For a free web host, the characteristics are:

Advertisement- most of the free web host is providing their hosting service free, but with some conditions applied. They require some amount of space on your website for advertisements or pop-up windows to advertise the sponsors. Thus if you are signing up for a free web host, be prepared to sacrifice some of the space for advertisement.

Amount of web space-there is a limited amount of web space for your website. The needs vary according to the types of media used, such as images or video clips. Usually, websites use less than 5MB of web space. If you are using simple designs, it is unlikely that you will use up this limit.

FTP access- this is an important must-have element. It is the ability to upload your pages vy browser or email. There are some free web hosts that only allow designing your website with their online builder. Although this is really helpful for beginners, it is the barrier for advanced expansion of your website. They might not be providing facilities for experienced users.

Types of files and size- free web hosts might impose a maximum size of each of the files or the types of the files to be uploaded.

Speed of access- you risk of losing your loyal visitors and traffic if the website is always down or very slow in page-loading. It is very frustrating when visitors have to wait for such a long time before your page can be fully loaded. Worse still, if the host is unreliable, your website may be inaccessible and one who is intending to visit your website will have to look for other websites.

Bandwidth allowance- most of the free web hosts restrict the amount of traffic your website can use daily and monthly. Once the limit is reached, your website will be disabled and you might receive a bill for that. The bandwidth that your website uses varies according to its usage and the number of traffic.

PHP or CGI-BIN access- there are a lot of free CGI hosting services such as search engines, forms, polls, mailing lists or counters for your website without the need for you to do these yourself. But if you want to do it yourself, you require either PHP or CGI-BIN access. However you must know the kind of environment that your scripts are running under.

You must be very careful while choosing for a free web host. Read thoroughly for the offers, limitations and even reviews by the experienced available on the Internet. If the offers and terms are not what you need, go for other web host with better offer. Again, free web host is most suitable for personal websites and not commercial websites.

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